Stress and Your Body
Course Overview
Discover how stress is negatively affecting your health and learn new strategies to minimize its impact in this course taught by a MacArthur “Genius.”
Course No. 1585
This 24-lecture course with renowned neurobiologist Professor Sapolsky reveals:
- Why modern humans suffer chronic stress while animals don’t
- How stress damages every major body system
- The biological links between stress and depression/anxiety
- Science-backed techniques to manage daily stressors
Using primate studies and clinical research to explain our stress response system.
Video Lectures
Module 1: Stress Fundamentals
- Why Don’t Zebras Get Ulcers? Why Do We? (31 min)
Introduction to stress science and human-animal differences. - The Nuts and Bolts of the Stress-Response (31 min)
Nervous system and hormonal reactions to stress.
Module 2: Physical Impacts
- Stress and Your Heart (31 min)
How chronic stress damages cardiovascular health. - Stress, Metabolism, and Liquidating Your Assets (31 min)
Stress-induced diabetes and energy mismanagement. - Stress, Overeating, and Your Digestive Tract (31 min)
IBS, ulcers, and stress-related eating patterns.
Module 3: Development & Reproduction
- Stress and Growth: Echoes from the Womb (31 min)
Prenatal stress effects and parenting styles. - Stress, Growth, and Child Development (31 min)
Stress dwarfism and the importance of nurturing. - Stress and Female Reproduction (30 min)
Fertility, miscarriages, and IVF challenges. - Stress and Male Reproduction (32 min)
Erectile dysfunction and testosterone changes.
Module 4: Immunity & Cognition
- Stress and Your Immune System (31 min)
Autoimmune flare-ups and infection vulnerability. - Stress and Cancer (31 min)
Examining controversial stress-cancer links. - Stress and Pain (29 min)
Bidirectional relationship between stress/pain. - Stress, Learning, and Memory (29 min)
How stress affects hippocampus and memory.
Module 5: Psychological Effects
- Stress, Judgment, and Impulse Control (31 min)
Frontal cortex impairment from chronic stress. - Stress, Sleep, and Lack of Sleep (31 min)
Disrupted sleep cycles and restoration. - Stress and Aging (31 min)
Accelerated aging from lifetime stress exposure.
Module 6: Stress Management
- Understanding Psychological Stress (30 min)
Outlets, social support, and predictability. - Psychological Modulators of Stress (30 min)
Control and interpretation factors. - Stress and the Biology of Depression (31 min)
Neurochemical links between stress and depression. - Stress and the Psychology of Depression (30 min)
Integrating biological/psychological models.
Module 7: Behavioral Impacts
- Anxiety, Hostility, Repression, and Reward (31 min)
Stress-induced personality changes. - Stress, Health, and Low Social Status (30 min)
Socioeconomic factors in stress vulnerability.
Module 8: Coping Strategies
- Stress Management: Clues to Success? (30 min)
Predictors of resilient aging. - Stress Management: Approaches and Cautions (32 min)
Exercise, meditation, and social support techniques.

